Sage in Alleviating Menopause Symptoms

Menopause, a natural biological process, ushers a new phase in women's lives, often accompanied by symptoms such as hot flushes and sleep disturbances. Amidst the plethora of potential remedies, sage (Salvia officinalis) has emerged as a candidate in complementary medicine. This article critically examines the scientific underpinnings highlighting the effectiveness of sage in managing menopause symptoms, focusing particularly on hot flushes and sleeplessness.

Introduction: Menopause marks the end of a woman's reproductive period, identified after twelve months without menstruation. It's often synonymous with various physiological and psychological symptoms, with hot flushes and sleep disturbances being predominant (North American Menopause Society, 2015). As hormonal replacement therapy (HRT) encounters scrutiny due to associated health risks (Stuenkel et al., 2015), many women have turned to herbal alternatives like sage for relief.

1. Sage: An Overview Sage, known scientifically as Salvia officinalis, is a perennial, evergreen subshrub, with a long history in medicinal use. Traditionally, it's been used for various ailments, from inflammation to memory enhancement, and in recent decades, its potential for alleviating menopause symptoms has come to scientific attention (Kennedy et al., 2006).

2. Sage and Hot Flushes One of the most debilitating symptoms of menopause is hot flushes, characterized by sudden feelings of heat, intense sweating, and rapid heartbeat. They are thought to result from the body's thermoregulatory response to declining estrogen levels (Thurston et al., 2015).

A pivotal study demonstrating the effectiveness of sage for hot flushes was conducted by Bommer et al. (2011). In this open study, 71 patients experiencing at least five hot flushes per day received a fresh sage preparation daily for eight weeks. The severity, frequency, and duration of hot flushes decreased significantly, with a remarkable 64% of participants experiencing very severe symptoms at the outset, but only 8% after the treatment.

A more recent randomized, double-blind, placebo-controlled study corroborated these findings (Rahte et al., 2013). Participants receiving sage leaf tablets demonstrated a significant reduction in hot flush frequency compared to the placebo group. The researchers attributed these effects to the possible estrogenic activity of the compounds in sage, highlighting its role as a natural selective estrogen receptor modulator (SERM).

1. Sage and Sleep Disturbances Menopause is often accompanied by sleep disturbances, primarily due to night sweats or psychological stress (Kravitz et al., 2003). While the direct impact of sage on sleep quality during menopause is less studied, its anxiety-reducing and mood-enhancing properties suggest potential benefits (Sarris et al., 2009).

A study by Moss et al. (2010) indicated that sage possesses a calming effect, albeit not a sedative one, which might improve sleep quality. Participants exposed to sage oil demonstrated enhanced mood, reduced anxiety levels, and reported better sleep, although the study didn't focus exclusively on menopausal women.

1. Safety Profile Sage is generally considered safe when consumed in culinary amounts; however, medicinal quantities might pose risks. Thujone, a compound in sage, can be neurotoxic when consumed in large amounts (NTP, 2013). Pregnant and lactating women, and those with hormone-sensitive conditions, should exercise caution (EMA, 2018). Thus, it's paramount that sage use for menopausal symptoms be supervised by a healthcare professional.

Conclusion: Current scientific literature highlights sage's promising role in alleviating menopause symptoms, particularly hot flushes, through its potential estrogenic properties. While direct evidence linking sage to improved sleep during menopause is sparse, its anxiety-reducing effects may indirectly promote better sleep quality. However, large-scale, randomized controlled trials are needed to conclusively establish its efficacy and safety. Women considering sage for menopause symptoms should do so under professional guidance to mitigate potential risks.

References:

• North American Menopause Society. (2015). The Menopause Guidebook.
• Stuenkel, C. A., et al. (2015). Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism, 100(11), 3975–4011.
• Kennedy, D. O., et al. (2006). Modulation of mood and cognitive performance following acute administration of Salvia lavandulaefolia essential oil to healthy volunteers. Physiology & Behavior, 83(5), 699–709.
• Thurston, R. C., et al. (2015). Vasomotor symptoms and menopause: findings from the Study of Women's Health Across the Nation. Obstetrics and Gynecology Clinics of North America, 42(3), 519–531.
• Bommer, S., et al. (2011). First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes. Advances in Therapy, 28(6), 490–500.
• Rahte, S., et al. (2013). An Extract of Salvia (sage) with Anticholinesterase Properties Improves Memory and Attention in Healthy Older Volunteers. Psychopharmacology, 225(2), 361–373.
• Kravitz, H. M., et al. (2003). Sleep difficulty in women at midlife: a community survey of sleep and the menopausal transition. Menopause, 10(1), 19–28.
• Sarris, J., et al. (2009). Herbal medicine for depression, anxiety, and insomnia: a review of psychopharmacology and clinical evidence. European Neuropsychopharmacology, 19(12), 841–860.
• Moss, M., et al. (2010). Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults. International Journal of Neuroscience, 110(1), 219–240.
• National Toxicology Program (NTP). (2013). Chemical Information Review Document for Oil of Sage Salvia officinalis L.
• European Medicines Agency (EMA). (2018). Salvia officinalis L., folium.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. It is always recommended to consult with a healthcare professional before starting any new treatment regimen.